Nucleic Acid Precipitation: Added to ethanol or isopropanol precipitations to recover DNA and RNA efficiently using 2M Sodium Acetate, pH 4.5.

RNA Isolation and Enrichment: Acidic conditions favor RNA precipitation and help minimize DNA and protein carryover.

DNA Cleanup after Organic Extraction: Improves phase separation and DNA recovery following phenol–chloroform extraction.

Cation-Exchange Chromatography: Serves as an acetate buffer for protein and peptide separation at low pH.

Enzyme Reactions at Acidic pH: Provides stable buffering for acid-active enzymes (e.g., glycosidases, acid phosphatases).

Buffer Exchange/Dialysis: Used to transition samples into acetate buffer conditions prior to downstream workflows.

Precipitation of Contaminating Proteins: Low pH acetate conditions aid removal of proteins during nucleic acid prep.

Library Prep and Cleanup: Supports nucleic acid concentration steps in NGS and cloning workflows.