Protein Purification: Removes contaminating DNA/RNA and lowers lysate viscosity to improve clarification, chromatography, and filtration of protein extracts.

Cell Lysis and Clarification: Degrades nucleic acids in lysates from Escherichia coli, yeast, and mammalian cells to prevent clumping and speed centrifugation/filtration.

Bioprocessing (Host Cell DNA Reduction): Reduces residual DNA/RNA in upstream and downstream processes to meet regulatory limits for biologics.

Viral Vector Manufacturing: Digests unpackaged nucleic acids during AAV and lentiviral production, improving purity and reducing viscosity.

Vaccine Production: Lowers host cell nucleic acid impurities in bacterial and mammalian expression systems for cleaner antigen preparations.

Sample Preparation for Microscopy: Clears nucleic acid background to improve particle visualization in EM and cryo-EM workflows.

Enzyme and Antibody Prep: Eliminates nucleic acids from protein formulations to stabilize viscosity and enhance downstream assay performance.

Cell Culture Debris Management: Minimizes DNA-mediated cell clumping after lysis or shear, aiding clarification of mammalian and microbial cultures.

Industrial Fermentation: Improves processing of high-cell-density broths (e.g., Bacillus subtilis, E. coli) by reducing viscosity and enhancing filterability.

Nucleic Acid Contamination Control: Used to lower background DNA/RNA in preparative workflows prior to mass spectrometry or proteomics.