Protein Refolding: 1M Arginine Solution is used to suppress aggregation and enhance refolding yields of denatured proteins.

Protein Purification: Added to IMAC and ion-exchange buffers to minimize nonspecific interactions and improve target protein elution.

Antibody Formulation: Serves as a stabilizer to reduce aggregation and viscosity in monoclonal antibody formulations.

Ultrafiltration/Diafiltration (UF/DF): Improves filterability and prevents aggregation during concentration and buffer exchange steps.

Size-Exclusion Chromatography (SEC): Included in mobile phases to increase protein solubility and reduce secondary interactions, improving peak shape.

Sample Preparation for SDS-PAGE/Western Blot: Enhances solubility of aggregation-prone proteins to improve band quality and recovery.

Protein Storage Buffers: Used to formulate storage conditions at pH 8.5 that stabilize proteins and enzymes over time.

Virus and Vector Stabilization: Added during purification and formulation to stabilize AAV and other viral vectors against aggregation.

Protein Crystallography: Employed in screening and optimization to mitigate aggregation and improve crystal quality.