Plasmid DNA Purification: Uses Cesium Chloride (1.4 g/mL) with ethidium bromide for isopycnic ultracentrifugation to isolate supercoiled plasmids from Escherichia coli.

Viral Vector Purification: Creates equilibrium density gradients with Cesium Chloride (1.4 g/mL) to purify AAV and adenovirus particles from protein and nucleic acid contaminants.

Bacteriophage Isolation: Employs Cesium Chloride (1.4 g/mL) gradients to concentrate and purify phages (e.g., lambda, T4) propagated in Escherichia coli.

Genomic DNA Density Separation: Uses Cesium Chloride (1.4 g/mL) to resolve DNA by buoyant density/GC content for analytical ultracentrifugation and purity assessment.

Stable Isotope Probing (SIP): Separates 13C-labeled microbial DNA from unlabeled DNA in Cesium Chloride (1.4 g/mL) gradients (e.g., from Escherichia coli or Bacillus subtilis).

Lipoprotein Fractionation: Utilizes Cesium Chloride (1.4 g/mL) density gradients to separate HDL, LDL, and VLDL from serum.

Endotoxin Reduction in Plasmid Preps: Applies Cesium Chloride (1.4 g/mL)–ethidium bromide gradients to reduce LPS contamination in DNA preparations.

RNA and RNP Purification: Uses Cesium Chloride (1.4 g/mL) cushion/gradients to purify high-molecular-weight RNA and ribonucleoprotein complexes.