AAV Vector Genome Titering (qPCR/ddPCR): Prepares AAV samples via DNase I digestion and controlled dilution to quantify encapsidated genomes accurately.

Removal of Extracapsid DNA: Eliminates residual plasmid and host DNA to distinguish packaged vector genomes from free nucleic acids in PCR assays.

Background Reduction in PCR: Decreases non-specific amplification by digesting contaminating DNA prior to amplification.

Process and Lot Release QC: Standardizes sample prep for consistent AAV QC workflows across batches.

Upstream Sample Cleanup: Treats crude lysates, media, and purified AAV to remove carryover DNA before PCR analysis.

Compatibility with ddPCR Workflows: Enables absolute quantification of AAV genomes by minimizing inhibitory and contaminating DNA.

Host/Plasmid DNA Clearance: Reduces carryover genomic DNA and residual plasmid DNA from production cells and Escherichia coli sources.

Standardized Dilution for Assay Linearity: Provides defined dilution conditions to maintain PCR linearity and reproducibility.