Plasmid DNA Purification (Alkaline Lysis Neutralization): 3M Potassium Acetate neutralizes alkaline lysates and precipitates SDS–protein–chromosomal DNA complexes during minipreps from Escherichia coli.

Nucleic Acid Precipitation: Supplies potassium ions to promote ethanol/isopropanol precipitation and concentration of DNA and RNA.

RNA Cleanup: Enhances selective precipitation of RNA and removal of polysaccharides and protein contaminants.

Removal of SDS and Proteins: Facilitates precipitation of SDS and protein contaminants from cell lysates during nucleic acid extraction.

Genomic DNA Isolation: Assists salt-dependent precipitation and cleanup steps for high-quality DNA recovery.

Acetate Buffering (pH 5.5): Serves as an acetate buffer component at pH 5.5 for assays requiring mildly acidic conditions.

Ion-Exchange Chromatography: Used as an acetate buffer/salt at acidic pH for equilibration or elution in anion-exchange workflows.

Protein Crystallization Screens: Functions as an acetate salt at pH 5.5 in crystallization condition matrices.

Gel Extraction Cleanup: Supports precipitation-based cleanup of DNA following gel extraction.