AAV Affinity Eluate Neutralization: Immediately neutralizes low-pH eluates from AAV affinity chromatography to protect capsid integrity and genome stability.

Downstream Processing Prep: Adjusts eluate pH prior to buffer exchange, desalting, or tangential flow filtration to maintain particle stability.

Assay Compatibility: Conditions samples for titering and analytical assays (e.g., ELISA, HPLC) by bringing eluates to a physiological pH.

Formulation and Storage: Provides a Tris-based environment to stabilize AAV preparations before final formulation or short-term hold.

Scale-Up Purification Workflows: Enables consistent neutralization across small- to large-scale AAV purification runs for reproducible recovery.

Capsid Preservation During Handling: Minimizes acid-induced aggregation or degradation during elution collection and pooling.