AAV Affinity CIP1 Solution is an acidic cleaning-in-place reagent for chromatography workflows involving recombinant adeno-associated virus (AAV). It is used to clean AAV affinity columns and system flow paths after product elution by removing process-derived impurities such as host cell proteins, nucleic acids, lipids, and residual feed components. It is applicable to affinity resins designed for common AAV serotypes and related engineered capsids.

The solution is intended for use according to column and system manufacturer instructions for contact time, linear velocity, and temperature, followed by thorough flushing and re-equilibration with the designated binding buffer. Store in the original container under standard laboratory chemical storage conditions, and handle using appropriate personal protective equipment and corrosion-resistant materials.