DNA Storage and Stabilization: Long-term storage of plasmid and genomic DNA; Tris maintains pH while EDTA chelates divalent cations to inhibit DNases.

RNA Storage (RNase-Free): Short- to medium-term storage of purified RNA and cDNA in a nuclease-free, pH-stable environment.

Resuspension of Nucleic Acids: Reconstitution of lyophilized oligonucleotides, plasmids, and DNA/RNA pellets after precipitation.

Elution Buffer for Purification: Elution of DNA from spin columns, magnetic beads, and gel extraction workflows to enhance stability post-purification.

Diluent for Sensitive Workflows: Dilution of DNA/RNA for qPCR, RT-qPCR, NGS library prep, and cloning to minimize nuclease activity (dilute to 1X as needed).

Template Preservation for PCR: Storage of PCR templates (e.g., plasmids from Escherichia coli) to protect integrity prior to amplification.

In Situ Hybridization/Probe Handling: Stabilization and storage of DNA/RNA probes for hybridization assays.

General Molecular Biology Handling: Safe buffer for routine transport, aliquoting, and archival of nucleic acids between enzymatic steps.