DNA Precipitation: Facilitates ethanol/isopropanol precipitation of genomic and plasmid DNA from aqueous solutions.

RNA Precipitation: Enhances recovery and cleanup of RNA in downstream workflows.

Plasmid DNA Purification: Used in buffering/wash steps for plasmid prep from Escherichia coli; endotoxin-tested for transfection-grade DNA.

Cation-Exchange Chromatography: Serves as equilibration and elution buffer at acidic pH for protein capture and separation.

Heparin/Affinity Chromatography: Employed as equilibration/wash buffer for nucleic acid–binding proteins requiring moderate ionic strength.

Enzyme Assays: Provides stable pH 5.5 for acid-active enzymes such as acid phosphatases and glycosidases.

Viral Vector Processing: Sterile, endotoxin-tested buffer for AAV/LV polishing steps requiring low pH and defined salt.

Histone/Chromatin Workflows: Supports acid extraction and handling of DNA–protein complexes.

Dialysis and Buffer Exchange: Used to transition samples to pH 5.5 with physiological ionic strength.

Sample Storage/Resuspension: Suitable for resuspending proteins and reagents for endotoxin-sensitive applications.