Nucleic Acid Elution: Elutes plasmid DNA and RNA from silica-based columns under mildly acidic, low-ionic-strength conditions for endotoxin-sensitive workflows.

Anion Exchange Chromatography: Lowers pH to reduce protein net negative charge, enabling efficient elution from anion-exchange resins.

Immunoaffinity Elution: Provides mild acidic conditions for eluting antibodies or antigens from Protein A/G/L matrices with rapid post-elution neutralization.

Peptide Cleanup: Serves as an acidic eluent for reverse-phase SPE peptide desalting prior to LC-MS analysis.

Desalting and Buffer Exchange: Used as an elution buffer in size-exclusion or desalting columns to recover biomolecules in a clean, endotoxin-tested, sterile matrix.

Endotoxin-Sensitive Prep: Suitable for workflows involving biomolecules produced in Escherichia coli (E. coli) where low endotoxin carryover is critical.

Protein Refolding/Recovery: Assists in pH-shift protocols that transiently acidify samples to release bound ligands or contaminants prior to neutralization.

General Laboratory Elution: Provides a consistent 20 mM acetic acid environment for mild pH-driven elution steps across diverse biomolecule purification schemes.