pH Adjustment of Buffers and Media: Used to raise and precisely control pH during buffer and cell culture media preparation.

Alkaline Lysis for Plasmid Prep: Employed to lyse Escherichia coli cells in standard plasmid DNA extraction workflows.

Chromatography Column Cleaning (CIP): Applied for cleaning and regeneration of ion-exchange and other chromatography resins.

Bioreactor and Process System Sanitization: Utilized for caustic cleaning of bioreactors, tanks, and fluid paths to reduce bioburden and endotoxins.

Membrane Cleaning (UF/TFF Systems): Used to remove fouling from ultrafiltration and tangential flow filtration membranes.

Endotoxin Inactivation on Equipment: Applied in depyrogenation rinses to inactivate and remove endotoxins from contact surfaces.

Fermentation pH Control: Used by automated control loops to maintain optimal culture pH during growth of organisms such as Escherichia coli or Bacillus subtilis.

Glassware and Labware Decontamination: Employed for alkaline cleaning to remove nucleases and organic residues.