pH Adjustment of Media and Buffers: Added as a sterile base to adjust pH in cell culture media, buffers, and reagents in GMP workflows.

Titration and Neutralization: Used for precise neutralization of acidic solutions and routine titrations in analytical and QC labs.

Bioreactor pH Control: Employed as a base addition for in-process pH control during upstream fermentation and cell culture.

Chromatography Buffer Preparation: Adjusts pH of equilibration, wash, and elution buffers for protein purification under regulated conditions.

Equipment Rinses and Cleaning Procedures: Utilized in base rinses and cleaning steps where a sterile, endotoxin-tested alkali is required.

Alkaline Lysis Workflows: Supports alkaline lysis steps (e.g., plasmid prep) where controlled NaOH concentration and sterility are important.

Nucleic Acid and Protein Sample Preparation: Applied for denaturation or hydrolysis steps that require mild alkaline conditions.

Method and Process Validation: Suitable for GMP-compliant procedures requiring traceable, ISO 13485–manufactured base.